Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of kidney health. It is not considered as reliable as creatinine or BUN-to-creatinine ratio blood studies. However, its important to note that the specific reference range provided by the laboratory conducting the test. On average, for adults, the normal range of BUN is between 6 to 20 milligrams per deciliter (mg/dL). The test is used to detect kidney problems. The normal range of BUN differs across age groups and can vary based on different factors and the laboratorys reference range. Individual laboratories may have different reference ranges, as they may use different assays. Normal human adult blood should contain 7 to 18 mg/dL (0.388 to 1 mmol/L) of urea nitrogen. Labs can use different methods to measure BUN or report BUN in different units, and what constitutes a normal result can vary from lab to lab. The liver produces urea in the urea cycle as a waste product of the digestion of protein. General reference ranges for a normal BUN level are as follows: Adults up to 60 years of age: 6-20 mg/dL Adults over 60 years of age: 8-23 mg/dL However, these ranges will likely vary. The American Board of Internal Medicine lists a typical reference range for BUN as eight to 20 mg/dL. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood.
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